Research Background & Mechanism
MOTS-c (mitochondrial-derived peptide) is a mitochondrial-derived peptide with a molecular weight of 2174.6 Da. Understanding its mechanism — a mitochondrial-encoded peptide studied for metabolic regulation — matters because it defines which experimental models the peptide is suited for and which controls a lab should run.
For researchers designing a protocol, the practical takeaway is to match the peptide to a specific, testable hypothesis rather than to a broad research area. MOTS-c (mitochondrial-derived peptide) is most consistently cited in work on mitochondrial signalling and metabolic regulation models, so that is where the published literature will give you the most guidance.
Purity & Quality Standards
The baseline specification for MOTS-c should be ≥98% by HPLC with MS confirmation. High-performance liquid chromatography reports the purity percentage, while mass spectrometry confirms that the material is actually MOTS-c (mitochondrial-derived peptide) at the expected molecular weight (2174.6 Da) — the two checks are complementary, not redundant.
Beyond purity, verify the salt form and any residue from synthesis (such as TFA removal) on the certificate of analysis. These details are easy to overlook but can shift results in sensitive assays, so they are part of any serious supplier-verification checklist.
Storage & Handling
The correct storage condition for MOTS-c is lyophilized at -20°C. Lyophilized peptide held at this temperature keeps its stated purity far longer than material left at ambient temperature, and the difference is measurable over months of routine use.
Once reconstituted, stability drops quickly, so laboratories should refrigerate solutions and use them within the window defined by their own protocol. Plan reconstitution just before use rather than in advance.
Sourcing & Supplier Verification
A reliable MOTS-c supplier should provide a batch-specific COA showing HPLC ≥98% and an MS spectrum at 2174.6 Da, and should be transparent about synthesis capacity and lead times. Suppliers that cannot produce these documents are the primary source of sub-standard or mis-identified material.
For bulk research purchasing, request the COA before committing to a large order, and confirm the peptide is sold strictly for laboratory and research use. A supplier that markets research peptides with therapeutic language is a red flag for compliance.
Frequently Asked Questions
Q1: What documentation should accompany MOTS-c?
A batch COA showing HPLC purity ≥98% and an MS spectrum matching 2174.6 Da; reject any supplier that can’t provide both.
Q2: Why is MS verification critical for MOTS-c?
MOTS-c is short (16 aa), so a sequencing error is easy to miss by HPLC alone; MS confirms the exact molecular weight.
Q3: Does MOTS-c require special handling?
Standard peptide handling applies: lyophilized at -20°C, refrigerated and used promptly after reconstitution.
Important: All products are sold strictly for laboratory and research purposes only — not for human or veterinary use. No medical, therapeutic, or dosing guidance is provided or implied. Researchers are responsible for compliance with their institution and local regulations.
📞 WhatsApp: +852 4419 8097 — batch-specific COA documents, bulk research pricing, and current stock for your lab.