The only meaningful difference between CJC-1295 no DAC and CJC-1295 DAC is the DAC (Drug Affinity Complex) modification, which binds the peptide to serum albumin and dramatically extends its half-life in circulation. Without DAC, the peptide clears much faster; with DAC, it persists far longer. That single chemical difference changes which version belongs in which experimental design.
This is one of the most common points of confusion I see in sourcing conversations. Labs sometimes order “CJC-1295” without realizing there are two chemically distinct versions, then wonder why their results do not line up with the literature. The fix is to be explicit about the DAC status on every order.
What the DAC Modification Does
The Drug Affinity Complex is a chemical modification that causes the peptide to bind reversibly to albumin, which slows clearance and produces a much longer active half-life.
- CJC-1295 no DAC — the unmodified peptide; shorter half-life, faster clearance.
- CJC-1295 DAC — albumin-bound; extended half-life, prolonged presence in circulation.
For research, the choice is about kinetics. A short-half-life peptide lets you study acute, time-controlled effects. A long-half-life peptide is better suited to studies where continuous exposure is the goal.
Purity and Verification
Both forms should ship with a batch-specific COA showing ≥98% purity by HPLC, plus mass spectrometry that confirms the molecular weight matches the DAC-modified or unmodified sequence. The DAC modification changes the molecular weight, so the MS readout is how you confirm you received the correct version.
| Attribute | CJC-1295 no DAC | CJC-1295 DAC |
|---|---|---|
| Modification | None | Drug Affinity Complex |
| Half-life | Short | Extended (albumin-bound) |
| Typical research use | Acute, time-controlled studies | Continuous-exposure studies |
| Verification | HPLC + MS | HPLC + MS (confirms DAC) |
How to Order Without Confusion
Always specify “no DAC” or “DAC” explicitly on the purchase order, and confirm the molecular weight on the COA matches the version you requested. This is the single most effective way to avoid receiving the wrong variant.
FAQ
What is the actual difference between CJC-1295 no DAC and CJC-1295 DAC?
The DAC modification binds the peptide to serum albumin, extending its half-life from short to long, while the no-DAC form clears much faster. Everything else about the base sequence is essentially the same.
Which version should I use in my study?
Choose no DAC for acute, time-controlled experiments and DAC for studies requiring continuous exposure over a longer window. The decision is driven by kinetics, not by which version is “stronger.”
How can I confirm I received the correct version?
Check the mass spectrometry report on the COA — the DAC modification produces a measurably different molecular weight than the unmodified peptide. If the MS does not match the version you ordered, contact the supplier before use.
What purity standard applies to CJC-1295?
The research-grade standard is ≥98% purity by HPLC with matching mass spectrometry, for both the DAC and no-DAC forms.
Contact Our Research Team
For batch-specific COA documents, bulk pricing, or current stock availability, reach us on WhatsApp (+852 4419 8097) or browse the full catalog at tb500.pro.
Important: All products are sold strictly for laboratory and research purposes only — not for human or veterinary use. No medical or dosing guidance is provided.