MOTS-c Research Review 2026: The Mitochondrial-Derived Peptide Explained

What Makes MOTS-c Different

MOTS-c is a 16-amino-acid mitochondrial-derived peptide with a molecular weight of 2174.7 Da, encoded within the mitochondrial 12S rRNA region rather than the nuclear genome. That unusual origin is why it attracts interest in metabolic and mitochondrial-function research.

As a relatively short peptide, MOTS-c is straightforward to synthesize, but the research literature on it is still developing — so source from a supplier that can provide clean, verified material and clear batch documentation.

Purity and Verification

Research-grade MOTS-c should carry an HPLC report of ≥98% purity with mass spec confirming the 2174.7 Da mass. Confirm the lyophilized powder is vacuum-sealed and the fill weight is clearly stated.

  • HPLC ≥98%: the research-grade purity floor
  • MS at 2174.7 Da: confirms the correct sequence mass
  • Vacuum-sealed: moisture protection for the lyophilized powder

FAQ

What is the molecular weight of MOTS-c?

MOTS-c has a molecular weight of 2174.7 Da and is a 16-amino-acid peptide.

Why is MOTS-c called a mitochondrial-derived peptide?

MOTS-c is encoded within the mitochondrial 12S rRNA region, unlike most peptides encoded by nuclear DNA.

How is MOTS-c stored?

Store lyophilized MOTS-c at -20°C, protected from light and moisture. Refrigerate the reconstituted solution.

Important: All products are sold strictly for laboratory and research purposes only — not for human or veterinary use. No medical or dosing guidance is provided.

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